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Halushka, Perry
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keywords Regulation of Thromboxane A2 Receptors in Health and Disease
overview Perry V. Halushka, M.D., Ph.D. is a Distinguished University Professor of Cell and Molecular Pharmacology, the Program Director of Medical Scientist Training Program, and dean emeritus of the College of Graduate Studies. He received his Ph.D. degree in 1967 and M.D. degree in 1970 from the University of Chicago. After internship and residency in Internal Medicine at Grady Memorial Hospital, he spent two years at the NIH, Experimental Therapeutics Branch. In 1974, he joined the faculty of the Medical University of South Carolina. Dr. Halushka¹s research has revolved around molecular characterizations and regulation of Thromboxane A2 receptors in health and disease. "The long term objective of our research program is to determine the role of thromboxane A2 receptors in disease processes with a particular emphasis in cancer. In collaboration with Drs. Omar Moussa and Dennis Watson we have found that there is an over-expression of the beta isoform of thromboxane A2 receptors in bladder cancer tissue and cell lines. The over-expression is associated with a poorer prognosis in patients with bladder cancer. Current studies are focused on determining the mechanisms for: 1) the over-expression of the receptors and 2) the signaling pathways involved in the oncogenic effects. The observations made in these studies may have wider applicability to other cancers."
One or more keywords matched the following items that are connected to Halushka, Perry
Item TypeName
Academic Article Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase.
Academic Article Expression, characterization, and purification of C-terminally hexahistidine-tagged thromboxane A2 receptors.
Academic Article Modification on ligand binding to TXA2/PGH2 receptors by diethylpyrocarbonate.
Academic Article Suppressed thromboxane production in endotoxin-desensitized THP-1 cells is not a result of decreased prostaglandin H synthase activity.
Academic Article Cloning and characterization of an endogenous COS-7 cell thromboxane A2 receptor.
Academic Article Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.
Academic Article Thromboxane A(2) receptors: where have you gone?
Academic Article Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2?
Academic Article Characterization of thromboxane A2/prostaglandin H2 receptors of various tissues using a new radioiodinated thromboxane A2/prostaglandin H2 mimetic, I-BOP.
Academic Article 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor.
Academic Article Castration reduces platelet thromboxane A2 receptor density and aggregability.
Academic Article Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with acute myocardial infarction.
Academic Article Endotoxin tolerance differentially alters hemodynamic responses to a thromboxane A2 mimetic and phenylephrine.
Academic Article Interactions of dihydropyridine Ca2+ channel agonists with the human platelet thromboxane A2/prostaglandin H2 receptor.
Academic Article Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis.
Academic Article Thromboxane and prostacyclin receptors.
Academic Article Pharmacology of thromboxane A2 receptor antagonists.
Academic Article Difluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vessels.
Academic Article Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors.
Academic Article Thromboxane A2 receptors are influenced by cell density in cultured rat aortic smooth muscle cells.
Academic Article Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets.
Academic Article Platelet and vascular thromboxane A2/prostaglandin H2 receptors. Evidence for different subclasses in the rat.
Academic Article Testosterone increases thromboxane A2 receptors in cultured rat aortic smooth muscle cells.
Academic Article Polymyxin B increases TXA2/PGH2 agonist and antagonist affinities in human platelet membranes.
Academic Article Photoaffinity labelling of a thromboxane A2/prostaglandin H2 antagonist binding site in human platelets.
Academic Article Platelet and vascular smooth muscle thromboxane A2/prostaglandin H2 receptors.
Academic Article Decrease in agonist affinity for human platelet thromboxane A2/prostaglandin H2 receptors induced by a platelet-derived supernatant.
Academic Article Subcellular localization of a thromboxane A2/prostaglandin H2 receptor antagonist binding site in human platelets.
Academic Article Different pharmacologic activities for 13-azapinane thromboxane A2 analogs in platelets and blood vessels.
Academic Article Desensitization of platelet thromboxane A2/prostaglandin H2 receptors by the mimetic U46619.
Academic Article A novel approach for the study of thromboxane A2 and prostaglandin H2 receptors using an 125I-labeled ligand.
Academic Article Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors.
Academic Article Binding of an 125I-labeled thromboxane A2/prostaglandin H2 receptor antagonist to washed canine platelets.
Academic Article Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets.
Academic Article Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle.
Academic Article Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes.
Academic Article Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock.
Academic Article Increased thromboxane level in experimental spinal cord injury.
Academic Article Thromboxane A2 in health and disease.
Academic Article Binding of thromboxane A2/prostaglandin H2 agonists to human platelets.
Academic Article Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to guinea-pig platelets.
Academic Article Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury.
Academic Article Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production.
Academic Article Implications for thromboxane A2 in the pathogenesis of endotoxic shock.
Academic Article Increased platelet thromboxane synthesis in diabetes mellitus.
Academic Article Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets.
Academic Article Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs.
Academic Article Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.
Academic Article Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets.
Academic Article Agonist-induced phosphorylation of human platelet TXA2/PGH2 receptors.
Academic Article 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors.
Academic Article Androgen regulation of thromboxane A2/prostaglandin H2 receptor expression in human erythroleukemia cells.
Academic Article Thromboxane A2 receptors.
Academic Article Activation of thromboxane A2 receptors alters lipopolysaccharide-induced adherence of THP-1 cells.
Academic Article Gender-related differences in androgen regulation of thromboxane A2 receptors in rat aortic smooth-muscle cells.
Academic Article Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition.
Academic Article Characterization of thromboxane A2/prostaglandin H2 receptors in human vascular smooth muscle cells.
Academic Article Photoaffinity receptor antagonist for human platelet thromboxane A2/prostaglandin H2 receptors.
Academic Article Radioligand binding assays for thromboxane A2/prostaglandin H2 receptors.
Academic Article Characterization of the vascular thromboxane A2/prostaglandin endoperoxide receptor in rabbit aorta. Regulation by dexamethasone.
Academic Article Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor.
Academic Article Photoaffinity labelling and isoelectric focusing of the human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor.
Academic Article Human erythroleukemia cells express functional thromboxane A2/prostaglandin H2 receptors.
Academic Article Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor.
Academic Article Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist.
Academic Article Cultured human vascular smooth muscle cells with functional thromboxane A2 receptors: measurement of U46619-induced 45calcium efflux.
Academic Article Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets.
Academic Article The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets.
Academic Article Hydrodynamic properties of a thromboxane A2/prostaglandin H2 antagonist binding site solubilized from human platelets.
Academic Article Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to washed human platelets.
Academic Article Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia.
Academic Article Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients.
Academic Article Insulin and arachidonic acid metabolism in diabetes mellitus.
Academic Article Further studies on the effects of epimers of thromboxane A2 antagonists on platelets and veins.
Academic Article Plasma thromboxane concentrations are raised in patients dying with septic shock.
Academic Article Thromboxane and prostacyclin in disease: a review.
Academic Article Thromboxane and prostacyclin production during septic shock.
Academic Article Thromboxane A2 and prostacyclin production by lipopolysaccharide-stimulated peritoneal macrophages.
Academic Article Sensitization of essential fatty acid-deficient rats to endotoxin by arachidonate pretreatment: role of thromboxane A2.
Academic Article Elevated thromboxane levels in the rat during endotoxic shock: protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency.
Academic Article Sex steroid regulation of thromboxane A2 receptors in cultured rat aortic smooth muscle cells.
Academic Article Testosterone regulation of platelet and vascular thromboxane A2 receptors.
Academic Article Androgen regulation of thromboxane A2 receptors.
Academic Article Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine.
Academic Article Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses.
Academic Article The Gordon Wilson Lecture. Regulation of thromboxane A2 receptors by testosterone: implications for steroid abuse and cardiovascular disease.
Academic Article Decrease in vascular TxA2 receptors in a subgroup of rabbits unresponsive to a TxA2 mimetic.
Academic Article Characterization of human peripheral blood monocyte thromboxane A2 receptors.
Academic Article Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney.
Academic Article Thromboxane A2/prostaglandin H2 receptors in streptozotocin-induced diabetes: effects of insulin therapy in the rat.
Academic Article Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with pregnancy induced hypertension.
Academic Article Thromboxane A2 receptors in equine monocytes: identification of a new subclass of TXA2 receptors.
Academic Article Characterization of rat glomerular thromboxane A2 receptors: comparison to rat platelets.
Academic Article Androstenedione increases thromboxane A2 receptors in human erythroleukemia cells.
Academic Article Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q.
Academic Article Stimulation of rat mesangial cell thromboxane A2 receptors inhibits particulate but not soluble guanylyl cyclase.
Academic Article Inhibition of testosterone 5 alpha-reductase: evidence for tissue-specific regulation of thromboxane A2 receptors.
Academic Article Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass.
Concept Receptors, Thromboxane A2, Prostaglandin H2
Concept Thromboxane A2
Academic Article Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer.
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  • Thromboxane A2